Centrosome Duplication: Is Asymmetry the Clue?
نویسندگان
چکیده
The structure of the yeast Sfi1-centrin complex, and its asymmetric position within the yeast centrosome, suggest a model for the initiation of centrosome duplication and provides a target for licensing this event.
منابع مشابه
Centrosome Duplication: Suspending a License by Phosphorylating a Template
The phosphorylation status of Sfi1, a structural component of the yeast centrosome, governs the centrosome duplication cycle, raising the possibility that licensing of centrosome duplication occurs by modulating Sfi1, which potentially acts as a template for a new centrosome.
متن کاملCyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells
Centrosome duplication is indispensable for the formation of the bipolar mitotic spindle. Surprisingly, even if DNA replication or mitosis is inhibited, centrosome duplication can still occur [1] [2] [3] [4] [5]. Thus, it remains unknown how centrosome duplication is coordinated with the cell cycle. Here, we show that centrosome duplication requires cyclin-dependent kinase 2 (Cdk2) in mammalian...
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BACKGROUND INFORMATION Centrosome duplication normally parallels with DNA replication and is responsible for correct segregation of replicated DNA into the daughter cells. Although geminin interacts with Cdt1 to prevent loading of MCMs (minichromosome maintenance proteins) on to the replication origins, inactivation of geminin nevertheless causes centrosome over-duplication in addition to the r...
متن کاملThe Replication Protein Cdc6 Suppresses Centrosome Over-Duplication in a Manner Independent of Its ATPase Activity
The Cdc6 protein is essential for the initiation of chromosomal replication and functions as a licensing factor to maintain chromosome integrity. During the S and G2 phases of the cell cycle, Cdc6 has been found to inhibit the recruitment of pericentriolar material (PCM) proteins to the centrosome and to suppress centrosome over-duplication. In this report, we analyzed the correlation between t...
متن کاملEverything in moderation
The presence of too many or too few centrosomes at mitosis can disrupt the timely formation of a bipolar spindle and may lead to aneuploidy and cancer. Strict control of centrosome duplication is therefore crucial. Centrosome duplication must occur once per cell cycle and the number of new centrioles made must be tightly controlled. The importance of protein degradation for the orderly progress...
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عنوان ژورنال:
- Current Biology
دوره 16 شماره
صفحات -
تاریخ انتشار 2006